POLYCLONAL C3D

Code: 403A-74 D2-231

General description

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complem...


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€285.00 EACH
€350.55 inc. VAT

General description

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. C3d deposition in the renal transplant PTCs (peritubular capillaries) is indicative of AR (acute rejection) with subsequent high probability of graft loss. Anti-C3d, combined with anti-C4d, can be utilized as a tool for diagnosis of AR and warrant prompt and aggressive anti-rejection treatment.In another study, Pfaltz et al. have shown that anti-C3d labeled the epidermal basement membrane in 97% (31/32) cases of bullous pemphigoid (BP), with none of the normal controls demonstrating such findings. In the same study 27% (3/11) cases of pemphigus vulgaris (PV) demonstrated intercellular C3d deposition. Therefore, C3d immunohistochemistry is a helpful adjunct in the diagnosis of BP (and perhaps PV), especially in the cases in which only formalin-fixed, paraffin embedded tissue is available for analysis.

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

C3d Positive Control Slides, Product No. 403S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Quality

IVDIVDIVDRUO

antibody formIg fraction of antiserum
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
conjugateunconjugated
descriptionFor In Vitro Diagnostic Use in Select Regions (See Chart)
formbuffered aqueous solution
Gene Informationhuman ... CR2(1380)
manufacturer/tradenameCell Marque
packagingbottle of 1.0 mL predilute (403A-77), vial of 0.5 mL concentrate (403A-75), vial of 1.0 mL concentrate (403A-76), vial of 0.1 mL concentrate (403A-74), bottle of 7.0 mL predilute (403A-78)
Quality Level100, 500
shipped inwet ice
species reactivityhuman
storage temp.2-8°C
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
visualizationcytoplasmic, membranous
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